Concomitant cocrystal and salt: no interconversion in the solid state

A cocrystal and a molecular salt of β‐alanine and dl‐tartaric acid, C3H8NO2+·C4H4O6−, of the same chemical composition, were studied over a wide temperature range by single‐crystal and powder X‐ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were o...

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Bibliographic Details
Published in:Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2019-03, Vol.75 (3), p.313-319
Main Authors: Losev, Evgeniy A., Boldyreva, Elena
Format: Article
Language:English
Subjects:
Alanine
Chemical composition
cocrystal
crystal structure
dl‐tartaric acid
Melting points
molecular salt
Organic chemistry
Phase transitions
Salts
Slurries
solvent‐mediated phase transformation
Tartaric acid
Temperature
X-ray diffraction
β‐alanine
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Summary:A cocrystal and a molecular salt of β‐alanine and dl‐tartaric acid, C3H8NO2+·C4H4O6−, of the same chemical composition, were studied over a wide temperature range by single‐crystal and powder X‐ray diffraction. Neither the interconversion between the two phases nor any polymorphic transitions were observed in the temperature range from 100 K to the melting points. This contrasts with the solvent‐mediated phase transition from the salt to the cocrystal in a slurry that has been documented earlier. A cocrystal and a molecular salt of β‐alanine and dl‐tartaric acid do not interconvert in the solid state over a wide temperature range, though such a transformation can be solvent‐mediated.
ISSN:2053-2296
0108-2701
2053-2296
1600-5759
DOI:10.1107/S2053229619001372