Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer

Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n...

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Bibliographic Details
Published in:Cancer investigation 2019-02, Vol.37 (2), p.85-89
Main Authors: Nichols, R. Charles, Morris, Christopher G., Bryant, Curtis, Hoppe, Bradford S., Henderson, Randal H., Mendenhall, William M., Li, Zuofeng, Costa, Joseph A., Williams, Christopher R., Mendenhall, Nancy P.
Format: Article
Language:English
Subjects:
Bladder and prostate cancer
Proton therapy
Radiation oncology
Serum testosterone
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Summary:Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60+ months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0-974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0-1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357907.2019.1565766