Prognostic Factors in Early-stage NSCLC: Analysis of the Placebo Group in the MAGRIT Study

The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, M...

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Bibliographic Details
Published in:Anticancer research 2019-03, Vol.39 (3), p.1403-1409
Main Authors: Cho, Byoung Chul, DE Pas, Tommaso, Kalofonos, Haralabos, Wang, Qun, Ramlau, Rodryg, Cheng, Ying, Vitiello, Fabiana, Laisaar, Tanel, Vallières, Eric, Kubisa, Bartosz, Orlov, Sergey, Park, Keunchil, Debruyne, Channa, Vansteenkiste, Johan
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - pathology
Double-Blind Method
Factor analysis
Female
Histopathology
Humans
Lung cancer
Lung Neoplasms - pathology
Male
Medical prognosis
Middle Aged
Multivariate analysis
Non-small cell lung carcinoma
Patients
Placebos
Prognosis
Regression analysis
Regression models
Squamous cell carcinoma
Surgery
Survival
Survival Analysis
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Summary:The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned to placebo in the MAGRIT study (NCT00480025). We explored characteristics of NSCLC that could predict DFS and OS using Cox regression models. The multivariate analysis showed that lower nodal stage, the presence of squamous cell carcinoma (SCC), a broader surgical resection in patients with SCC, and being female with non-SCC were significantly associated with longer DFS. Lower nodal stage and smaller tumor size were significantly associated with an improved OS. Compared to Other International, enrollment in East Asia was associated with an improved OS in patients with non-SCC. This is the first prognostic factor analysis in NSCLC performed on data from a large prospective study. These results confirm retrospective studies and add that histopathology subtype is a strong determinant of DFS in resected MAGE-A3-positive NSCLC.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13255