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Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses
The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, w...
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| Published in: | Anticancer research 2019-03, Vol.39 (3), p.1343-1346 |
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| Main Authors: | , , , , , |
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| container_start_page | 1343 |
| container_title | Anticancer research |
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| creator | Hansen, Heinke C Janssen, Stefan Thieme, Cathrin Perlov, Aleksej Schild, Steven E Rades, Dirk |
| description | The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation.
The interval between diagnosis of brain metastases and WBRT and ten other factors were retrospectively analyzed for survival in 191 patients surviving 4 months or longer following WBRT.
On univariate analyses, Eastern Cooperative Oncology Group (ECOG) performance score of 0-1, 1-3 brain metastases and absence of extra-cerebral metastases were significantly associated with longer survival, whereas the interval from diagnostic imaging to WBRT was not. On multivariate analysis, ECOG performance score remained significant, and extra-cerebral metastases showed a trend towards a longer survival.
The interval between diagnostic imaging and WBRT didn't have a significant impact on patients surviving 4 months or longer. Depending on the need for symptom relief, WBRT may be postponed for very important reasons such as obtaining a multidisciplinary tumor board decision or definitive histology. |
| doi_str_mv | 10.21873/anticanres.13247 |
| format | article |
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The interval between diagnosis of brain metastases and WBRT and ten other factors were retrospectively analyzed for survival in 191 patients surviving 4 months or longer following WBRT.
On univariate analyses, Eastern Cooperative Oncology Group (ECOG) performance score of 0-1, 1-3 brain metastases and absence of extra-cerebral metastases were significantly associated with longer survival, whereas the interval from diagnostic imaging to WBRT was not. On multivariate analysis, ECOG performance score remained significant, and extra-cerebral metastases showed a trend towards a longer survival.
The interval between diagnostic imaging and WBRT didn't have a significant impact on patients surviving 4 months or longer. Depending on the need for symptom relief, WBRT may be postponed for very important reasons such as obtaining a multidisciplinary tumor board decision or definitive histology.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.13247</identifier><identifier>PMID: 30842167</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Aged ; Brain ; Brain cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - secondary ; Breast Neoplasms - pathology ; Colorectal Neoplasms - pathology ; Cranial Irradiation ; Diagnostic systems ; Female ; Histology ; Humans ; Irradiation ; Kaplan-Meier Estimate ; Lung Neoplasms - pathology ; Male ; Medical imaging ; Melanoma - pathology ; Metastases ; Metastasis ; Multivariate analysis ; Neoplasms, Unknown Primary - pathology ; Neuroimaging ; Oncology ; Patients ; Prognosis ; Radiation therapy ; Survival ; Tomography, X-Ray Computed</subject><ispartof>Anticancer research, 2019-03, Vol.39 (3), p.1343-1346</ispartof><rights>Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Mar 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-523f955a427eaf951a14721f93098ea4aabbbe2febff7292a6546f38f5e47ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30842167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, Heinke C</creatorcontrib><creatorcontrib>Janssen, Stefan</creatorcontrib><creatorcontrib>Thieme, Cathrin</creatorcontrib><creatorcontrib>Perlov, Aleksej</creatorcontrib><creatorcontrib>Schild, Steven E</creatorcontrib><creatorcontrib>Rades, Dirk</creatorcontrib><title>Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation.
The interval between diagnosis of brain metastases and WBRT and ten other factors were retrospectively analyzed for survival in 191 patients surviving 4 months or longer following WBRT.
On univariate analyses, Eastern Cooperative Oncology Group (ECOG) performance score of 0-1, 1-3 brain metastases and absence of extra-cerebral metastases were significantly associated with longer survival, whereas the interval from diagnostic imaging to WBRT was not. On multivariate analysis, ECOG performance score remained significant, and extra-cerebral metastases showed a trend towards a longer survival.
The interval between diagnostic imaging and WBRT didn't have a significant impact on patients surviving 4 months or longer. Depending on the need for symptom relief, WBRT may be postponed for very important reasons such as obtaining a multidisciplinary tumor board decision or definitive histology.</description><subject>Aged</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - secondary</subject><subject>Breast Neoplasms - pathology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cranial Irradiation</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Histology</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Melanoma - pathology</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Neoplasms, Unknown Primary - pathology</subject><subject>Neuroimaging</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Survival</subject><subject>Tomography, X-Ray Computed</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLJDEUhYM4aOv4A9wMATezKSePqkpqqeKjQZjGEVwWt6pvuiPVSZukWvoPzO82PkZhVsm5OefjkkPIMWengmslf4FLtgcXMJ5yKUq1QyZcNbxQlWS7ZMJExQrFWLVPDmJ8ZKyuGy33yL5kuhS8VhPyd-YTZgoMdLpaQ5-oNzQtkU5dwrDJ43NMz4guP8PCugUFN6cPSz9g0QWwjt7B3PqcCLDe0qxnkGwmRvpg05Le4ZD1BoctvYKND9ANSP-MYWNf2bPgF85HjN_JNwNDxKOP85DcX13eX9wUt7-vpxdnt0UvlUhFJaRpqgpKoRDyjQMvleCmkazRCCVA13UoDHbGKNEIqKuyNlKbCkuFRh6Sn-_YdfBPI8bUrmzscRjAoR9jm39VN1qoUmfryX_WRz8Gl5drheBMNkpzmV383dUHH2NA066DXUHYtpy1bx21Xx21bx3lzI8P8titcP6Z-FeKfAGzt5HH</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Hansen, Heinke C</creator><creator>Janssen, Stefan</creator><creator>Thieme, Cathrin</creator><creator>Perlov, Aleksej</creator><creator>Schild, Steven E</creator><creator>Rades, Dirk</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201903</creationdate><title>Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses</title><author>Hansen, Heinke C ; 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Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation.
The interval between diagnosis of brain metastases and WBRT and ten other factors were retrospectively analyzed for survival in 191 patients surviving 4 months or longer following WBRT.
On univariate analyses, Eastern Cooperative Oncology Group (ECOG) performance score of 0-1, 1-3 brain metastases and absence of extra-cerebral metastases were significantly associated with longer survival, whereas the interval from diagnostic imaging to WBRT was not. On multivariate analysis, ECOG performance score remained significant, and extra-cerebral metastases showed a trend towards a longer survival.
The interval between diagnostic imaging and WBRT didn't have a significant impact on patients surviving 4 months or longer. Depending on the need for symptom relief, WBRT may be postponed for very important reasons such as obtaining a multidisciplinary tumor board decision or definitive histology.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>30842167</pmid><doi>10.21873/anticanres.13247</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Brain Brain cancer Brain Neoplasms - diagnostic imaging Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Breast Neoplasms - pathology Colorectal Neoplasms - pathology Cranial Irradiation Diagnostic systems Female Histology Humans Irradiation Kaplan-Meier Estimate Lung Neoplasms - pathology Male Medical imaging Melanoma - pathology Metastases Metastasis Multivariate analysis Neoplasms, Unknown Primary - pathology Neuroimaging Oncology Patients Prognosis Radiation therapy Survival Tomography, X-Ray Computed |
| title | Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses |
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