Ratiometric fluorescent probe for sensing Streptococcus mutans glucosyltransferase, a key factor in the formation of dental caries

We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from gre...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-03, Vol.55 (24), p.3548-3551
Main Authors: Feng, Lei, Yan, Qingsong, Zhang, Baojing, Tian, Xiangge, Wang, Chao, Yu, Zhenlong, Cui, Jingnan, Guo, Dean, Ma, Xiaochi, James, Tony D
Format: Article
Language:English
Subjects:
Dental caries
Fluorescent indicators
Green tea
Polyphenols
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Summary:We report on a naphthalimide ratiometric fluorescent probe for the real-time sensing and imaging of pathogenic bacterial glucosyltransferases, which are associated with the development of dental caries. Using a high-throughput screening method, we identified that several natural polyphenols from green tea were GTFs inhibitors that could eventually lead to suitable oral treatments to prevent the development of dental caries.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00440h