Serum cytokine patterns in immunoglobulin m monoclonal gammopathy‐associated polyneuropathy

ABSTRACT Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM‐PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B‐cell‐stimulating cytokines are increased...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2019-06, Vol.59 (6), p.694-698
Main Authors: Stork, Abraham C. J., Rijkers, Ger T., Vlam, Lotte, Cats, Elisabeth A., de Jong, Ben A. W., Fritsch‐Stork, Ruth D. E., Veldink, Jan H., van den Berg, Leonard H., Notermans, Nicolette C., van der Pol, W‐Ludo
Format: Article
Language:English
Subjects:
Antibodies
anti‐MAG neuropathy
Cytokines
Disease control
Gangliosides
Glycoproteins
Immunoglobulin M
Immunoglobulins
Interleukins
Lymphocytes B
Monoclonal gammopathy
multifocal motor neuropathy
Muscles
Myelin
Myelin-associated glycoprotein
peripheral neuropathy
Polyneuropathy
Progressive motor neuropathy
Subgroups
Test procedures
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM‐PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B‐cell‐stimulating cytokines are increased in IgM‐PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM‐PNP and 113 controls. Results: Median interleukin (IL)‐6 concentrations were higher in patients with IgM‐PNP, and median IL‐10 concentrations were higher in the subgroup with anti‐MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy. Discussion: Median IL‐6 and IL‐10 serum concentrations differ between patients with anti‐MAG neuropathy and other patients with IgM‐PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune‐mediated disease mechanisms. Muscle Nerve 59:694–698, 2019
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26462