Advancing Translational Research Using NIMH Research Domain Criteria and Computational Methods

The NIMH Research Domain Criteria (RDoC) can aid in the translation of integrative neuroscience. We argue that the RDoC framework, with its emphasis on integration across units of analysis, leveraged with computational approaches, can organize intermediary treatment targets and clinical outcomes, au...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2019-03, Vol.101 (5), p.779-782
Main Authors: Sanislow, Charles A., Ferrante, Michele, Pacheco, Jennifer, Rudorfer, Matthew V., Morris, Sarah E.
Format: Article
Language:English
Subjects:
Behavior
Cognitive ability
computational
Computing Methodologies
FDA approval
Humans
Mental disorders
Mental Disorders - therapy
Mental health care
National Institute of Mental Health (U.S.)
Nervous system
Neurosciences
Neurosciences - methods
NIMH
Precision medicine
Precision Medicine - methods
Psychopathology
Psychosis
RDoC
Researchers
Schizophrenia
Suicides & suicide attempts
Translation
translational
Translational Medical Research - methods
Translational Medical Research - organization & administration
treatment targets
United States
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Summary:The NIMH Research Domain Criteria (RDoC) can aid in the translation of integrative neuroscience. We argue that the RDoC framework, with its emphasis on integration across units of analysis, leveraged with computational approaches, can organize intermediary treatment targets and clinical outcomes, augmenting the translational stream. NIMH’s Research Domain Criteria is a framework for dimensional, trans-diagnostic research on mental disorders. Sanislow et al. discuss ways in which research leveraging computational methods can identify intermediary treatment targets and accelerate translational progress.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2019.02.024