Close Quarters Can Be a Good Fit for Stem Cells to Become T Cells

Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hemato...

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Bibliographic Details
Published in:Cell stem cell 2019-03, Vol.24 (3), p.345-347
Main Authors: Trotman-Grant, Ashton, Zúñiga-Pflücker, Juan Carlos
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Hematopoiesis
Humans
Mice
Organoids
Pluripotent Stem Cells
T-Lymphocytes
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Summary:Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentiation to enable commitment, selection, and maturation of conventional human T cells. Human pluripotent stem cells (PSCs) could potentially provide a potentially unlimited supply of T cells. In this issue of Cell Stem Cell, Montel-Hagen et al. (2019) take advantage of a three-dimensional mouse stromal cell-based system that combines mesoderm specification with organoid-induced hematopoietic differentiation to enable commitment, selection, and maturation of conventional human T cells.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2019.02.013