Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans

Highlights•Reactogenicity and inflammatory markers evaluated after HBsAg-adjuvanted vaccines. •Significant associations between systemic symptoms and IL-6 and IFN signals revealed. •Similar inflammatory signals were shown to be associated with the adaptive response.

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Bibliographic Details
Published in:Vaccine 2019-03, Vol.37 (14), p.2004-2015
Main Authors: Burny, Wivine, Marchant, Arnaud, Hervé, Caroline, Callegaro, Andrea, Caubet, Magalie, Fissette, Laurence, Gheyle, Lien, Legrand, Catherine, Ndour, Cheikh, Tavares Da Silva, Fernanda, van der Most, Robbert, Willems, Fabienne, Didierlaurent, Arnaud M, Yarzabal, Juan
Format: Article
Language:English
Subjects:
Adjuvants
Adults
Allergy and Immunology
Antigens
Association with systemic symptoms
Bilirubin
Blood
Blood levels
C-reactive protein
Clinical trials
Cytokines
Funding
HBsAg-AS01B adjuvanted vaccine
Hepatitis
Hepatitis B
Hepatitis B surface antigen
IFNγ signals
IL-6 signals
Immune response
Immune system
Immunization
Immunogenicity
Inflammation
Injection
Innate response
Interleukin 6
IP-10 protein
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
Leukocytes
Lymphocytes
Lymphocytes T
Monocytes
Parameter identification
Proteins
Reactogenicity
Regression analysis
Signs and symptoms
Vaccines
γ-Interferon
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Description
Summary:Highlights•Reactogenicity and inflammatory markers evaluated after HBsAg-adjuvanted vaccines. •Significant associations between systemic symptoms and IL-6 and IFN signals revealed. •Similar inflammatory signals were shown to be associated with the adaptive response.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2019.02.015