The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker

• Published in: Surgical oncology 2019-03, Vol.28, p.151-157
• Main Authors: Vizza, Enrico, Mancini, Emanuela, Laquintana, Valentina, Loria, Rossella, Carosi, Mariantonia, Baiocco, Ermelinda, Cicchillitti, Lucia, Piaggio, Giulia, Patrizi, Lodovico, Sperduti, Isabella, Zampa, Ashanti, Cutillo, Giuseppe, Falcioni, Rita, Corrado, Giacomo
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Clear Cell - metabolism; Adenocarcinoma, Clear Cell - pathology; Adenocarcinoma, Clear Cell - surgery; Aged; Biomarkers; Biomarkers, Tumor - metabolism; Cancer; Cancer therapies; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Case-Control Studies; Cell adhesion & migration; Cellular biology; Cystadenocarcinoma, Serous - metabolism; Cystadenocarcinoma, Serous - pathology; Cystadenocarcinoma, Serous - surgery; Cytodiagnosis; Cytology; Endometrial cancer; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Endometrium; Family medical history; Female; Follow-Up Studies; Humans; L1CAM; Laparoscopy; Lymphatic system; Medical prognosis; Middle Aged; Multivariate analysis; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Neural Cell Adhesion Molecule L1 - metabolism; Oncology; Patients; Peritoneal cytology; Peritoneal Neoplasms - metabolism; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - surgery; Peritoneum; Retrospective Studies; Risk analysis; Risk Factors; Studies; Surgery; Survival Rate
• ISSN: 0960-7404; 1879-3320; 1879-3320
• DOI: 10.1016/j.suronc.2019.01.001

The aim of this study was to evaluate the prognostic role of positive peritoneal cytology (PPC) in a cohort of patients with endometrial cancer (EC). The secondary objective was to correlate the PPC and the expression of L1CAM in a group of patients with recurrence endometrial disease. All women diagnosed with EC and who performed a peritoneal cytology at “Regina Elena” National Cancer Institute of Rome from 2001 to 2013 were included in the study. Patients were divided into two groups according to positivity at peritoneal cytology. Moreover, patients with a recurrence disease and whose a tissue microarray (TMA) tumor sample was available underwent a L1CAM analysis. Seven hundred sixty six patients underwent to EC staging in our Institute: 696 (90.8%) with negative and 70 (9.2%) with positive cytology. Five-year recurrence rate was higher in women with PPC (46.9% vs 18.4%, p = 0