Integrin intracellular machinery in action

Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic approaches have improved our understanding of how...

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Bibliographic Details
Published in:Experimental cell research 2019-05, Vol.378 (2), p.226-231
Main Authors: Green, Hannah J., Brown, Nicholas H.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Extracellular matrix
Humans
Integrin-associated proteins
Integrins
Integrins - physiology
Mechanotransduction
Mechanotransduction, Cellular
Membrane Proteins - physiology
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Summary:Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic approaches have improved our understanding of how each IAP contributes to integrin function, especially in the context of building a functional organism during development. We then begin the process of assembling IAP roles together into an integrated mechanism.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2019.03.011