Investigating transmission of Mycobacterium abscessus amongst children in an Australian cystic fibrosis centre

Mycobacterium abscessus is an emerging pathogen in cystic fibrosis (CF) lung disease. Hospital transmission of M. abscessus has been described. This paper details the investigation into possible cross-transmission of M. abscessus locally at our paediatric hospital CF centre, and the subsequent infec...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2020-03, Vol.19 (2), p.219-224
Main Authors: Yan, Jennifer, Kevat, Ajay, Martinez, Elena, Teese, Nicky, Johnson, Kareena, Ranganathan, Sarath, Harrison, Jo, Massie, John, Daley, Andrew
Format: Article
Language:English
Subjects:
Cystic fibrosis
Infection control
Mycobacterium abscessus
Non-tuberculous mycobacteria
Whole genome sequencing
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Summary:Mycobacterium abscessus is an emerging pathogen in cystic fibrosis (CF) lung disease. Hospital transmission of M. abscessus has been described. This paper details the investigation into possible cross-transmission of M. abscessus locally at our paediatric hospital CF centre, and the subsequent infection control response. Whole genome sequencing (WGS) of M. abscessus respiratory isolates with epidemiological linkage analysis using hospital electronic medical records. 6.7% (22/328) of CF patients had M. abscessus isolated from respiratory specimens. WGS revealed a cluster of three patients with genomically related isolates that differed by
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2019.02.011