Association of APOE and CETP TaqIB Polymorphisms with Type 2 Diabetes Mellitus

Apolipoprotein E (APOE) and cholesteryl ester transfer protein (CETP) play an important role in the lipid metabolism. Dyslipidemia is one of the complications that found in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to investigate the association of APOE and CETP TaqIB polym...

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Bibliographic Details
Published in:Archives of medical research 2018-10, Vol.49 (7), p.479-485
Main Authors: Srirojnopkun, Chatinun, Kietrungwilaikul, Kridtaporn, Boonsong, Katesaraphorn, Thongpoonkaew, Jetnarong, Jeenduang, Nutjaree
Format: Article
Language:English
Subjects:
APOE
CETP TaqIB
Polymorphisms
Type 2 diabetes
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Summary:Apolipoprotein E (APOE) and cholesteryl ester transfer protein (CETP) play an important role in the lipid metabolism. Dyslipidemia is one of the complications that found in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to investigate the association of APOE and CETP TaqIB polymorphisms with T2DM and its related metabolic parameters in Southern Thai population. Study subjects were 241 T2DM patients and 275 healthy controls. The APOE and CETP TaqIB polymorphisms were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique. APOE polymorphism showed a statistical difference in allele frequencies (p = 0.025) and genotype distributions (p 
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2019.02.005