The mesenchymal transition subtype more responsive to dose dense taxane chemotherapy combined with carboplatin than to conventional taxane and carboplatin chemotherapy in high grade serous ovarian carcinoma: A survey of Japanese Gynecologic Oncology Group study (JGOG3016A1)

Recently, we established new histopathological subtypes of high-grade serous ovarian cancer (HGSOC) that include the mesenchymal transition (MT) type, the immune reactive (IR) type, the solid and proliferative (SP) type and the papillo-glandular (PG) type. Furthermore, we identified that the mesench...

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Published in:Gynecologic oncology 2019-05, Vol.153 (2), p.312-319
Main Authors: Murakami, Ryusuke, Matsumura, Noriomi, Michimae, Hirofumi, Tanabe, Hiroshi, Yunokawa, Mayu, Iwase, Haruko, Sasagawa, Motoi, Nakamura, Toshiaki, Tokuyama, Osamu, Takano, Masashi, Sugiyama, Toru, Sawasaki, Takashi, Isonishi, Seiji, Takehara, Kazuhiro, Nakai, Hidekatsu, Okamoto, Aikou, Mandai, Masaki, Konishi, Ikuo
Format: Article
Language:English
Subjects:
Dose dense TC
High grade serous ovarian carcinoma
Mesenchymal
Ovarian cancer
Taxane sensitivity
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Summary:Recently, we established new histopathological subtypes of high-grade serous ovarian cancer (HGSOC) that include the mesenchymal transition (MT) type, the immune reactive (IR) type, the solid and proliferative (SP) type and the papillo-glandular (PG) type. Furthermore, we identified that the mesenchymal transcriptome subtype might be sensitive to taxane. We investigated whether these different histopathological subtypes of HGSOC require individualized chemotherapy for optimal treatment. We conducted the Japanese Gynecologic Oncology Group (JGOG) 3016A1 study, wherein we collected hematoxylin and eosin slides (total n = 201) and performed a histopathological analysis of patients with HGSOC registered in the JGOG3016 study, which compared the efficacy of conventional paclitaxel and carboplatin (TC) and dose-dense TC (ddTC). We analyzed the differences in progression-free survival (PFS) and overall survival (OS) among the four histopathological subtypes. We then compared the PFS between the TC group and the ddTC group for each histopathological subtype. There were significant differences in both PFS and OS among the four histopathological subtypes (p = 0.001 and p 
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2019.02.010