Incidence of second primary malignancy after breast cancer and related risk factors—Is breast‐conserving surgery safe? A nested case–control study

Risk of second primary malignancy (SPM) is increasing. We aimed to assess the incidence and related risk factors of SPM among breast cancer (BC) patients from this nested case–control study using the SEER database. BC patients with SPM were identified as the case group and SPM‐free patients were def...

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Bibliographic Details
Published in:International journal of cancer 2020-01, Vol.146 (2), p.352-362
Main Authors: Li, Zhuyue, Wang, Kang, Shi, Yang, Zhang, Xuemei, Wen, Jin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Breast - pathology
Breast - surgery
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - therapy
breast‐conserving surgery
Cancer
Case-Control Studies
Demographic variables
Female
Follow-Up Studies
Health risk assessment
Health risks
Humans
Incidence
Malignancy
Mastectomy, Segmental - adverse effects
Medical research
Middle Aged
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - etiology
Patients
Radiation therapy
radiotherapy
Radiotherapy, Adjuvant - statistics & numerical data
Receptors, Estrogen - metabolism
risk factor
Risk Factors
second primary malignancy
SEER Program - statistics & numerical data
Surgery
Young Adult
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Summary:Risk of second primary malignancy (SPM) is increasing. We aimed to assess the incidence and related risk factors of SPM among breast cancer (BC) patients from this nested case–control study using the SEER database. BC patients with SPM were identified as the case group and SPM‐free patients were defined as the control group. Propensity score matching of cases with controls by the year of the first primary BC diagnosis was conducted at the ratio of 1:5, and 97,242 BC patients were enrolled from 1998 to 2013 after the matching. The incidence of SPM in BC patients stratified by age groups and cancer sites was compared to the general population using the adjusted standardized incidence ratio (SIR) and the risk factors for SPM were examined using Cox proportional hazard regressions. Our study showed BC patients had excess risk for SPM than the general population (adjusted SIR for all cancer sites = 12.94, p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.32259