NLRC5: A paradigm for NLRs in immunological and inflammatory reaction

The nucleotide-binding domain leucine-rich repeat containing (NLR) family of proteins is mainly involved in microbial pathogen recognition, inflammatory responses, and cell death. NLRC5, the largest member of the NLR family, is currently receiving an increasing level of attention. NLRC5 has been dem...

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Bibliographic Details
Published in:Cancer letters 2019-06, Vol.451, p.92-99
Main Authors: Wu, Yuting, Shi, Tianlu, Li, Jun
Format: Article
Language:English
Subjects:
Adapter proteins
Antigens
Apoptosis
Arthritis
Autophagy
Cancers
Cell adhesion & migration
Cell death
Cell growth
Cell Line
Cytokines
Dendritic cells
Gene expression
Host defense
Humans
Immunology
Inflammation
Inflammation - immunology
Inflammation - physiopathology
Inflammatory response
Intracellular Signaling Peptides and Proteins - physiology
Leucine
Localization
Mammals
Molecular modelling
NF-kappa B - metabolism
NF-κB protein
NLRC5
NLRS
Physiology
Polypeptides
Proteins
Signal Transduction
Viral infections
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Summary:The nucleotide-binding domain leucine-rich repeat containing (NLR) family of proteins is mainly involved in microbial pathogen recognition, inflammatory responses, and cell death. NLRC5, the largest member of the NLR family, is currently receiving an increasing level of attention. NLRC5 has been demonstrated to be a potent negative regulator of NF-κB signaling pathway-mediated inflammatory response. Moreover, accumulating evidence has indicated that NLRC5 is closely related to pathological processes of various cancers. In this review, we present an overview on NLRC5, addressing its underlying molecular mechanisms and implications in host defense, inflammatory response, and associated cancers. •NLRC5 plays an important role in human immunological and inflammatory reaction.•We summarize the biogenesis of NLRC5 and discuss the molecular functions and interactions of NLRC5 in physiological and pathological processes.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2019.03.005