Glans penis necrosis caused by calcific uremic arteriolopathy

Calcific uremic arteriolopathy (CUA) or calciphylaxis is a syndrome characterized by calcification of vessels located in the dermis and adipose tissue. It commonly occurs in patients with diabetes mellitus, hypertension, and end-stage renal disease. Clinical presentation generally begins with severe...

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Bibliographic Details
Published in:Dermatology online journal 2019, Vol.25 (2)
Main Authors: Villela-Segura, Uriel, Peralta-Serna, Julieta, Guerrero-Álvarez, Alejandra, Estrada-Aguilar, Lorena
Format: Article
Language:English
Subjects:
Diabetes
Health risk assessment
Hypertension
Kidney diseases
Necrosis
Ulcers
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Summary:Calcific uremic arteriolopathy (CUA) or calciphylaxis is a syndrome characterized by calcification of vessels located in the dermis and adipose tissue. It commonly occurs in patients with diabetes mellitus, hypertension, and end-stage renal disease. Clinical presentation generally begins with severe pain, followed by the presence of liveloid or purpuric plaques. Later the formation necrotic ulcers occur. This condition is associated with a poor prognosis, with a high rate of mortality within months of the diagnosis. Penile involvement is an uncommon but severe manifestation. We present an 81-year-old man with a history of diabetes mellitus, hypertension, and end-stage renal disease with a one-month evolution of painful necrotic ulcers on his glans penis. He was diagnosed with CUA. Owing to infection complicated by sepsis; penectomy was performed. Unfortunately, the patient died of myocardial infarction during his hospitalization.
ISSN:1087-2108
1087-2108
DOI:10.5070/D3252042891