H3K27M-Positive Primary Spinal Glioblastoma Presenting with Hemorrhage—A Rare Clinical Entity

Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes We have presented an unusual case—the first, to the best of our knowledge, to be reported—with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multif...

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Bibliographic Details
Published in:World neurosurgery 2019-06, Vol.126, p.223-227
Main Authors: Uppar, Alok, Konar, Subhas K., B.N., Nandeesh, Shukla, Dhaval
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - metabolism
Cervical Cord - metabolism
Cervical Cord - pathology
Cervical Cord - surgery
Decompression, Surgical
Fatal Outcome
Female
Glioblastoma - complications
Glioblastoma - metabolism
Glioblastoma - pathology
Glioblastoma - surgery
H3K27M
Hemorrhage
Hemorrhage - etiology
Hemorrhage - metabolism
Hemorrhage - pathology
Hemorrhage - surgery
Humans
Primary spinal glioblastoma
Spinal Cord Neoplasms - complications
Spinal Cord Neoplasms - metabolism
Spinal Cord Neoplasms - pathology
Spinal Cord Neoplasms - surgery
Surgery
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Summary:Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes We have presented an unusual case—the first, to the best of our knowledge, to be reported—with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multiforme. The patient underwent emergency surgical decompression. The patient died after a prolonged intensive care unit stay. The tumor was positive for histone molecular alteration, H3K27M.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2019.03.025