Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

Aims Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles. Methods We used LC–MS/MS t...

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Bibliographic Details
Published in:Acta diabetologica 2019-04, Vol.56 (4), p.421-430
Main Authors: Shokry, Engy, Marchioro, Linda, Uhl, Olaf, Bermúdez, Mercedes G., García-Santos, Jose Antonio, Segura, Mª Teresa, Campoy, Cristina, Koletzko, Berthold
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Carnitine
Chromatography, Liquid
Cohort analysis
Cohort Studies
Cord blood
Diabetes
Diabetes mellitus
Diabetes, Gestational - metabolism
Fatty acids
Fatty Acids - metabolism
Fatty Acids, Nonesterified - metabolism
Female
Fetal Blood - metabolism
Health risk assessment
Humans
Infant, Newborn
Internal Medicine
Isoleucine
Leucine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolites
Metabolome
Obesity
Obesity - complications
Obesity - metabolism
Offspring
Organic acids
Original Article
Oxidation
Phospholipids
Phospholipids - metabolism
Pregnancy
Pregnancy and diabetes
Pregnancy Complications - metabolism
Prenatal Exposure Delayed Effects - metabolism
Risk Factors
Tandem Mass Spectrometry
Tricarboxylic acid cycle
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Summary:Aims Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles. Methods We used LC–MS/MS to measure 201 metabolites comprising phospholipids (PL), amino acids, non-esterified fatty acids (NEFA), organic acids, acyl carnitines (AC), and Krebs cycle metabolites in maternal plasma at delivery and cord plasma obtained from 325 PREOBE study participants. Results Several metabolites were associated with pBMI/GDM in both maternal and cord blood ( p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-019-01291-z