Cytosine base editors go off-target

Tools that can edit a single base pair in the genome hold promise for the treatment of human disease and crop improvement; however, little is known about their off-target effects. Jin et al. and Zuo et al. show that cytosine base editors (CBEs) (but not adenine base editors (ABEs)) induce notable of...

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Bibliographic Details
Published in:Nature reviews. Genetics 2019-05, Vol.20 (5), p.254-255
Main Author: Wrighton, Katharine H.
Format: Article
Language:English
Subjects:
631/1647/1511
631/1647/334/1874/345
631/1647/334/2244/1791
631/208/514/1948
631/449/447/2311
Agriculture
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
CRISPR
CRISPR-Cas Systems
Crop improvement
Cytosine
Deoxyribonucleic acid
DNA
Editors
Enzymes
Gene Editing
Gene Function
Genetic research
Genomes
Genomics
Human Genetics
Mice
Mutation
Nucleotides
Purines
Pyrimidines
Research Highlight
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Summary:Tools that can edit a single base pair in the genome hold promise for the treatment of human disease and crop improvement; however, little is known about their off-target effects. Jin et al. and Zuo et al. show that cytosine base editors (CBEs) (but not adenine base editors (ABEs)) induce notable off-target single-nucleotide variants (SNVs) in rice and in mouse embryos, respectively.
ISSN:1471-0056
1471-0064
DOI:10.1038/s41576-019-0110-x