Sentinel and non-sentinel lymph node metastases in patients with microinvasive breast cancer: a nationwide study

Purpose To determine the incidence and risk factors of sentinel lymph node (SN) and non-SN metastases in patients with microinvasive breast cancer (MIBC, T1 mic ). This to identify MIBC patients in whom axillary staging can be safely omitted. Methods The Danish Breast Cancer Group database was used...

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Bibliographic Details
Published in:Breast cancer research and treatment 2019-06, Vol.175 (3), p.713-719
Main Authors: Holm-Rasmussen, Emil Villiam, Jensen, Maj-Britt, Balslev, Eva, Kroman, Niels, Tvedskov, Tove Filtenborg
Format: Article
Language:English
Subjects:
Analysis
Biopsy
Breast cancer
Cancer
Cancer patients
Cancer research
Care and treatment
Epidemiology
Epidermal growth factor
ErbB-2 protein
Lymph nodes
Lymphatic system
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Oncology, Experimental
Patients
Risk factors
Surgery
Tumor cells
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Summary:Purpose To determine the incidence and risk factors of sentinel lymph node (SN) and non-SN metastases in patients with microinvasive breast cancer (MIBC, T1 mic ). This to identify MIBC patients in whom axillary staging can be safely omitted. Methods The Danish Breast Cancer Group database was used to identify a total of 409 women with breast cancer ≤ 1 mm who underwent sentinel lymph node biopsy (SLNB) between 2002 and 2015. After validation, 233 patients were eligible for the analysis. The incidence rates of SN and non-SN metastases were determined. The associations between clinicopathological variables and a positive SN [pN1, pN1mi, or pN0(i+)] were analyzed using univariate and multivariate designs. Results Of 233 patients with MIBC, only 9 (3.9%) had SN macrometastases. An additional 18 (7.7%) and 23 (9.9%) had SN micrometastases and isolated tumor cells (ITCs), respectively. Of patients with SN macrometastases, two (22.2%) had non-SN macrometastases. In the adjusted analysis, a positive SN was associated with younger age ( P  = 0.0001) and a positive human epidermal growth factor 2 receptor (HER2) status ( P  = 0.03). Conclusions The low incidence of SN macrometastases 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-019-05200-4