Bisphenol A analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study

Bisphenol A (BPA) is a well-known endocrine-disrupting chemical with estrogenic activity. The widespread exposure of individuals to BPA is suspected to affect a variety of physiological functions, including reproduction, development, and metabolism. Here we report the mechanisms by which BPA and thr...

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Bibliographic Details
Published in:Toxicology and industrial health 2019-04, Vol.35 (4), p.294-303
Main Authors: Ullah, Asad, Pirzada, Madeeha, Jahan, Sarwat, Ullah, Hizb, Khan, Muhammad Jamil
Format: Article
Language:English
Subjects:
Animal models
Bisphenol A
Chemical activity
Damage
Deoxyribonucleic acid
Disruption
DNA
DNA damage
DNA fragmentation
Endocrine disruptors
Estrogenic activity
In vivo methods and tests
Metabolism
Organic chemistry
Oxidative stress
Reactive oxygen species
Sperm
Spermatozoa
Superoxide dismutase
Xenoestrogens
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Summary:Bisphenol A (BPA) is a well-known endocrine-disrupting chemical with estrogenic activity. The widespread exposure of individuals to BPA is suspected to affect a variety of physiological functions, including reproduction, development, and metabolism. Here we report the mechanisms by which BPA and three of its analogues bisphenol B (BPB), bisphenol F (BPF), and bisphenol S (BPS) cause generation of reactive oxygen species (ROS), sperm DNA damage, and oxidative stress in both in vivo and in vitro rat models. Sperm were incubated with different concentrations (1, 10, and 100 µg/L) of BPA and its analogues BPB, BPF, and BPS for 2 h. BPA and its analogues were observed to increase DNA fragmentation, formation of ROS, and affected levels of superoxide dismutase at higher concentration groups. In an in vivo experiment, rats were exposed to different concentrations (5, 25, and 50 mg/kg/day) of BPA, BPB, BPF, and BPS for 28 days. In the higher dose (50 mg/kg/day) treated groups of BPA and its analogues BPB, BPF, and BPS, DNA damage was observed while the motility of sperm was not affected.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233719831528