The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matr...

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Bibliographic Details
Published in:Differentiation (London) 2019-03, Vol.106, p.49-56
Main Authors: Sánchez-Romero, Natalia, Sainz-Arnal, Pilar, Pla-Palacín, Iris, Dachary, Pablo Royo, Almeida, Helen, Pastor, Cristina, Soto, Daniela Rubio, Rodriguez, Milagros Chico, Arbizu, Emma Olmedo, Martinez, Lourdes Bengochea, Serrano-Aulló, Trinidad, Baptista, Pedro M.
Format: Article
Language:English
Subjects:
Biochemical characteristics
Biomechanics
Cell fate
Cell self-renewal
Cell survival
ECM
Embryos
Extracellular matrix
Growth factors
Hepatocytes
Liver development
Liver diseases
Mechanical properties
Mechanobiology
Phenotypes
Progenitor cell
Stem cell
Stem cell niche
Stem cells
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Summary:The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.
ISSN:0301-4681
1432-0436
DOI:10.1016/j.diff.2019.03.001