Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

Oxygen vacancy (OV) engineering in semiconductors can greatly enhance the separation of photo-induced electron-hole pairs, thereby enhancing the photocatalytic activity. Taking inspiration from this, we prepared a novel BiOBr-H/Rub d composite by functionalizing OV-rich BiOBr (named BiOBr-H) with a...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2019-02, Vol.10 (8), p.2336-2341
Main Authors: Guan, Shanyue, Wang, Li, Xu, Si-Min, Yang, Di, Waterhouse, Geoffrey I N, Qu, Xiaozhong, Zhou, Shuyun
Format: Article
Language:English
Subjects:
Catalytic activity
Density functional theory
Electron transfer
Energy levels
In vivo methods and tests
Light irradiation
Photocatalysis
Photodynamic therapy
Ruthenium compounds
Singlet oxygen
Vacancies
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Summary:Oxygen vacancy (OV) engineering in semiconductors can greatly enhance the separation of photo-induced electron-hole pairs, thereby enhancing the photocatalytic activity. Taking inspiration from this, we prepared a novel BiOBr-H/Rub d composite by functionalizing OV-rich BiOBr (named BiOBr-H) with a carboxyl functionalized ruthenium photosensitizer (Ru(bpy) C-pyCl , abbreviated as Rub d), which was then successfully applied for photodynamic therapy (PDT). Density functional theory (DFT) calculations confirmed efficient electron transfer from the Rub d complex to the intermediate energy level of BiOBr-H under visible light irradiation. and studies demonstrated that BiOBr-H/Rub d was a superior agent for photodynamic therapy compared with the free ruthenium complex. The theoretical and experimental data presented thus reveal for the first time that abundant OVs in BiOBr-H can significantly improve the photocatalytic activity of a photosensitizer, resulting in the generation of more reactive oxygen species to enhance PDT. The findings of this study thus offer a new strategy for the development of highly efficient cancer therapies.
ISSN:2041-6520
2041-6539
DOI:10.1039/c8sc05275a