Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization

Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marke...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cancer research and therapeutics 2019-01, Vol.15 (1), p.54-60
Main Authors: Bilgin, Burak, Sendur, Mehmet, Hizal, Mutlu, Dede, Didem, Akinci, Muhammed, Kandil, Sümeyye, Yaman, Samet, Yalçin, Abdussamet, Kiliç, Mehmet, Yalçin, Bülent
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anemia
Biopsy
Blood Platelets
Cancer cells
Colon - pathology
Colon - surgery
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Diagnosis
Disease
Disease-Free Survival
Erythrocyte Indices
Female
Gene expression
Humans
Inflammation
Localization
Male
Medical prognosis
Metastasis
Middle Aged
Mutation
Neoplasm Staging
Platelet Count
Population
Prognosis
Rectum - pathology
Rectum - surgery
Retrospective Studies
ROC Curve
Studies
Tumors
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marker for colon tumor. However, since most of these tests are expensive and unachievable, there is a need for new prognostic and predictive markers that can be used easily and are inexpensive. Aim: We aimed to investigate the prognostic effect of red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects inflammatory status and can be calculated basically by using center blood count (CBC) parameters on CRC according to tumor stage and localization. Methods: Newly diagnosed 312 CRC patients between 2010 and 2016 were retrospectively analyzed. Patients' demographics, including survival data and tumor characteristics, were obtained from medical charts. RPR was calculated using CBC parameters at the time of diagnosis. Cutoff value for RPR was set at 0.05 and the patient population was divided into two arms (arm A: RPR ≥0.05 and arm B: RPR
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.JCRT_624_17