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Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization
Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marke...
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| Published in: | Journal of cancer research and therapeutics 2019-01, Vol.15 (1), p.54-60 |
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| creator | Bilgin, Burak Sendur, Mehmet Hizal, Mutlu Dede, Didem Akinci, Muhammed Kandil, Sümeyye Yaman, Samet Yalçin, Abdussamet Kiliç, Mehmet Yalçin, Bülent |
| description | Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marker for colon tumor. However, since most of these tests are expensive and unachievable, there is a need for new prognostic and predictive markers that can be used easily and are inexpensive.
Aim: We aimed to investigate the prognostic effect of red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects inflammatory status and can be calculated basically by using center blood count (CBC) parameters on CRC according to tumor stage and localization.
Methods: Newly diagnosed 312 CRC patients between 2010 and 2016 were retrospectively analyzed. Patients' demographics, including survival data and tumor characteristics, were obtained from medical charts. RPR was calculated using CBC parameters at the time of diagnosis. Cutoff value for RPR was set at 0.05 and the patient population was divided into two arms (arm A: RPR ≥0.05 and arm B: RPR |
| doi_str_mv | 10.4103/jcrt.JCRT_624_17 |
| format | article |
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Aim: We aimed to investigate the prognostic effect of red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects inflammatory status and can be calculated basically by using center blood count (CBC) parameters on CRC according to tumor stage and localization.
Methods: Newly diagnosed 312 CRC patients between 2010 and 2016 were retrospectively analyzed. Patients' demographics, including survival data and tumor characteristics, were obtained from medical charts. RPR was calculated using CBC parameters at the time of diagnosis. Cutoff value for RPR was set at 0.05 and the patient population was divided into two arms (arm A: RPR ≥0.05 and arm B: RPR <0.05). The patients were stratified according to the tumor stage (early and advanced disease) and tumor localization (right sided and left sided).
Results: Totally, 312 patients were enrolled to the study. Nearly 81.9% of the patients were at early stage and 18.1% were at advanced stage at the time of diagnosis. In patients with early-stage disease, no significant disease-free survival and overall survival (OS) was found in both arms (P = 0.88 and P = 0.085, respectively). In arm A, OS was nonsignificantly better in the entire and left-sided advanced tumor compared to arm B. In patients with right-sided advanced cancer, OS was statistically significantly better for arm A compared to arm B (median OS; RPR ≥0.05: 24.8 months vs. <0.05: 13.9 months; P = 0.035).
Discussion: RPR can be a useful prognostic marker in CRC, especially in right-sided advanced tumors.
Conclusion: RPR can be used as a prognostic marker in CRC but should be validated with further investigation.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.JCRT_624_17</identifier><identifier>PMID: 30880755</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anemia ; Biopsy ; Blood Platelets ; Cancer cells ; Colon - pathology ; Colon - surgery ; Colorectal cancer ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Diagnosis ; Disease ; Disease-Free Survival ; Erythrocyte Indices ; Female ; Gene expression ; Humans ; Inflammation ; Localization ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Mutation ; Neoplasm Staging ; Platelet Count ; Population ; Prognosis ; Rectum - pathology ; Rectum - surgery ; Retrospective Studies ; ROC Curve ; Studies ; Tumors ; Young Adult</subject><ispartof>Journal of cancer research and therapeutics, 2019-01, Vol.15 (1), p.54-60</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-fc4dcfd553c39a9483848326d7d73b14d90497d02974c340856c36bf2f6fca063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2193108645?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,4024,25753,27923,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30880755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilgin, Burak</creatorcontrib><creatorcontrib>Sendur, Mehmet</creatorcontrib><creatorcontrib>Hizal, Mutlu</creatorcontrib><creatorcontrib>Dede, Didem</creatorcontrib><creatorcontrib>Akinci, Muhammed</creatorcontrib><creatorcontrib>Kandil, Sümeyye</creatorcontrib><creatorcontrib>Yaman, Samet</creatorcontrib><creatorcontrib>Yalçin, Abdussamet</creatorcontrib><creatorcontrib>Kiliç, Mehmet</creatorcontrib><creatorcontrib>Yalçin, Bülent</creatorcontrib><title>Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marker for colon tumor. However, since most of these tests are expensive and unachievable, there is a need for new prognostic and predictive markers that can be used easily and are inexpensive.
Aim: We aimed to investigate the prognostic effect of red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects inflammatory status and can be calculated basically by using center blood count (CBC) parameters on CRC according to tumor stage and localization.
Methods: Newly diagnosed 312 CRC patients between 2010 and 2016 were retrospectively analyzed. Patients' demographics, including survival data and tumor characteristics, were obtained from medical charts. RPR was calculated using CBC parameters at the time of diagnosis. Cutoff value for RPR was set at 0.05 and the patient population was divided into two arms (arm A: RPR ≥0.05 and arm B: RPR <0.05). The patients were stratified according to the tumor stage (early and advanced disease) and tumor localization (right sided and left sided).
Results: Totally, 312 patients were enrolled to the study. Nearly 81.9% of the patients were at early stage and 18.1% were at advanced stage at the time of diagnosis. In patients with early-stage disease, no significant disease-free survival and overall survival (OS) was found in both arms (P = 0.88 and P = 0.085, respectively). In arm A, OS was nonsignificantly better in the entire and left-sided advanced tumor compared to arm B. In patients with right-sided advanced cancer, OS was statistically significantly better for arm A compared to arm B (median OS; RPR ≥0.05: 24.8 months vs. <0.05: 13.9 months; P = 0.035).
Discussion: RPR can be a useful prognostic marker in CRC, especially in right-sided advanced tumors.
Conclusion: RPR can be used as a prognostic marker in CRC but should be validated with further investigation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Biopsy</subject><subject>Blood Platelets</subject><subject>Cancer cells</subject><subject>Colon - pathology</subject><subject>Colon - surgery</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Disease-Free Survival</subject><subject>Erythrocyte Indices</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Localization</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Platelet Count</subject><subject>Population</subject><subject>Prognosis</subject><subject>Rectum - pathology</subject><subject>Rectum - surgery</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Studies</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1ks2LEzEchgdR3Lp69yQBL16mJpNkkjmWsq7KgiLrOaT5GNNNk5pkKHrb_9yM3fWLSgiB5Hle8oO3aZ4juCQI4tdblcry_frTteg7IhB70CzQMPCWIMwfNgs4MNwiwruz5knOWwgp6zr-uDnDkHPIKF00tx9THEPMxSlgrDWqgGhBMhoo4z3QLpfkNlNxMYCD0-VLW2K797IYbwpIsj4AF4CKPqYqSw-UDMokIJWKSbswghJBmXYxgVzkaIAMGviopHffZzs8bR5Z6bN5dneeN5_fXFyv37ZXHy7frVdXraK4K61VRCurKcUKD3IgHPO6u14zzfAGET1AMjANu4ERhQnktFe439jO9lZJ2OPz5tUxd5_i18nkInYuz0PKYOKURYcG3HeIUl7Rl_-g2zilUH_3k0KQ94T-pkbpjXDBxpKkmkPFijLOGR4wq1R7ghpNMEn6GIx19fovfnmCr0ubnVMnBXgUVIo5J2PFPrmdTN8EgmJuiZhbIv5oSVVe3M03bXZG_xLua1GB1RE4RF9Myjd-OpgkKnsT4uG_wYIScd8n_APLwNBi</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Bilgin, Burak</creator><creator>Sendur, Mehmet</creator><creator>Hizal, Mutlu</creator><creator>Dede, Didem</creator><creator>Akinci, Muhammed</creator><creator>Kandil, Sümeyye</creator><creator>Yaman, Samet</creator><creator>Yalçin, Abdussamet</creator><creator>Kiliç, Mehmet</creator><creator>Yalçin, Bülent</creator><general>Wolters Kluwer India Pvt. 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Akinci, Muhammed ; Kandil, Sümeyye ; Yaman, Samet ; Yalçin, Abdussamet ; Kiliç, Mehmet ; Yalçin, Bülent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-fc4dcfd553c39a9483848326d7d73b14d90497d02974c340856c36bf2f6fca063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Biopsy</topic><topic>Blood Platelets</topic><topic>Cancer cells</topic><topic>Colon - pathology</topic><topic>Colon - surgery</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Disease-Free Survival</topic><topic>Erythrocyte Indices</topic><topic>Female</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Localization</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>Platelet Count</topic><topic>Population</topic><topic>Prognosis</topic><topic>Rectum - pathology</topic><topic>Rectum - surgery</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Studies</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilgin, Burak</creatorcontrib><creatorcontrib>Sendur, Mehmet</creatorcontrib><creatorcontrib>Hizal, Mutlu</creatorcontrib><creatorcontrib>Dede, Didem</creatorcontrib><creatorcontrib>Akinci, Muhammed</creatorcontrib><creatorcontrib>Kandil, Sümeyye</creatorcontrib><creatorcontrib>Yaman, Samet</creatorcontrib><creatorcontrib>Yalçin, Abdussamet</creatorcontrib><creatorcontrib>Kiliç, Mehmet</creatorcontrib><creatorcontrib>Yalçin, Bülent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilgin, Burak</au><au>Sendur, Mehmet</au><au>Hizal, Mutlu</au><au>Dede, Didem</au><au>Akinci, Muhammed</au><au>Kandil, Sümeyye</au><au>Yaman, Samet</au><au>Yalçin, Abdussamet</au><au>Kiliç, Mehmet</au><au>Yalçin, Bülent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>15</volume><issue>1</issue><spage>54</spage><epage>60</epage><pages>54-60</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide and survival is still approximately 24 months. Recently, importance of the molecular features, tumor localization, and also inflammatory status is increased, and most of these entities can be used as a predictive marker for colon tumor. However, since most of these tests are expensive and unachievable, there is a need for new prognostic and predictive markers that can be used easily and are inexpensive.
Aim: We aimed to investigate the prognostic effect of red cell distribution width (RDW)-to-platelet ratio (RPR) which reflects inflammatory status and can be calculated basically by using center blood count (CBC) parameters on CRC according to tumor stage and localization.
Methods: Newly diagnosed 312 CRC patients between 2010 and 2016 were retrospectively analyzed. Patients' demographics, including survival data and tumor characteristics, were obtained from medical charts. RPR was calculated using CBC parameters at the time of diagnosis. Cutoff value for RPR was set at 0.05 and the patient population was divided into two arms (arm A: RPR ≥0.05 and arm B: RPR <0.05). The patients were stratified according to the tumor stage (early and advanced disease) and tumor localization (right sided and left sided).
Results: Totally, 312 patients were enrolled to the study. Nearly 81.9% of the patients were at early stage and 18.1% were at advanced stage at the time of diagnosis. In patients with early-stage disease, no significant disease-free survival and overall survival (OS) was found in both arms (P = 0.88 and P = 0.085, respectively). In arm A, OS was nonsignificantly better in the entire and left-sided advanced tumor compared to arm B. In patients with right-sided advanced cancer, OS was statistically significantly better for arm A compared to arm B (median OS; RPR ≥0.05: 24.8 months vs. <0.05: 13.9 months; P = 0.035).
Discussion: RPR can be a useful prognostic marker in CRC, especially in right-sided advanced tumors.
Conclusion: RPR can be used as a prognostic marker in CRC but should be validated with further investigation.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>30880755</pmid><doi>10.4103/jcrt.JCRT_624_17</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anemia Biopsy Blood Platelets Cancer cells Colon - pathology Colon - surgery Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Diagnosis Disease Disease-Free Survival Erythrocyte Indices Female Gene expression Humans Inflammation Localization Male Medical prognosis Metastasis Middle Aged Mutation Neoplasm Staging Platelet Count Population Prognosis Rectum - pathology Rectum - surgery Retrospective Studies ROC Curve Studies Tumors Young Adult |
| title | Prognostic effect of red cell distribution width-to-platelet ratio in colorectal cancer according to tumor stage and localization |
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