Dendritic complexity in prefrontal cortex and hippocampus of the autistic-like mice C58/J

•The number of dendrites is lower in hippocampus of autistic mice compared to WT.•Dendritic processes are smaller in autistic mice compared to WT.•Length of dendrites in autistic mice is shorter compared to WT. Autism spectrum disorder (ASD) has been associated to atypical neuronal connectivity in t...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2019-06, Vol.703, p.149-155
Main Authors: Barón-Mendoza, Isabel, Del Moral-Sánchez, Ireri, Martínez-Marcial, Mónica, García, Octavio, Garzón-Cortés, Daniel, González-Arenas, Aliesha
Format: Article
Language:English
Subjects:
Autism
C58/J
Dendritic complexity
Hippocampus
Prefrontal cortex
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The number of dendrites is lower in hippocampus of autistic mice compared to WT.•Dendritic processes are smaller in autistic mice compared to WT.•Length of dendrites in autistic mice is shorter compared to WT. Autism spectrum disorder (ASD) has been associated to atypical neuronal connectivity in the prefrontal cortex (PFC) and the hippocampus, in part, due to an alteration in neuroplasticity processes such as dendritic remodeling. Moreover, it has been proposed that abnormal cytoskeletal dynamics might be underlying the disrupted formation and morphology of dendrites in the ASD brain. Hence, we performed an analysis of the complexity of dendritic arborization of the pyramidal neurons localized in the layer II/III of the PFC and the CA1 region of the hippocampus in the autistic-like mouse strain C58/J, which has previously demonstrated neuronal cytoskeleton anomalies. We found differences in length, number and branching pattern of dendrites of the pyramidal neurons from both structures of C58/J strain. These data suggest a lower dendritic arborization complexity that could be involved with the characteristic autistic-like behaviors displayed in C58/J mice.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2019.03.018