Cholecalciferol supplementation increases FGF23 in peritoneal dialysis patients with hypovitaminosis D: a randomized clinical trial

Background Vitamin D deficiency is common in peritoneal dialysis (PD) patients, so its supplementation has been advocated as potentially beneficial. Methods Double-blind, placebo-controlled, randomized clinical trial. Subjects on PD treated with high calcium peritoneal dialysate (Ca 3.5 mEq/l) and s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nephrology 2019-08, Vol.32 (4), p.645-659
Main Authors: Ramirez-Sandoval, Juan C., Arvizu-Hernandez, Mauricio, Cruz, Cristino, Vazquez-Cantu, Barbara, Rojas-Concha, Luis J., Tamez, Luis, Reynerio, Fagundo, Gomez, F. Enrique, Correa-Rotter, Ricardo
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Nephrology
Original Article
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Vitamin D deficiency is common in peritoneal dialysis (PD) patients, so its supplementation has been advocated as potentially beneficial. Methods Double-blind, placebo-controlled, randomized clinical trial. Subjects on PD treated with high calcium peritoneal dialysate (Ca 3.5 mEq/l) and serum levels of 25-hydroxi vitamin D (25D)  30,000 pg/ml) were observed in 74% of subjects receiving cholecalciferol although iFGF23 returned to baseline values after 32 weeks of withdrawal. The observed changes in iFGF23 correlated with 1,25D levels and were not modified by other variables. No difference was observed between groups in osteoprotegerin or other osteogenic biomarkers levels. Conclusions Cholecalciferol supplementation increases serum 25D levels in subjects on PD exposed to high calcium dialysate, yet it induces an exponential increase of iFGF23 in most patients, which disappear after withdrawal of supplementation and may be a major concern for this maneuver.
ISSN:1121-8428
1724-6059
DOI:10.1007/s40620-019-00599-x