Functionalized mesoporous silica nanoparticles and biomedical applications

Since the first report in early 1990s, mesoporous silica nanoparticles (MSNs) have progressively attracted the attention of scientists due to their potential applications in physic, energy storage, imaging, and especially in biomedical engineering. Owning the unique physiochemical properties, such a...

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Bibliographic Details
Published in:Materials Science & Engineering C 2019-06, Vol.99, p.631-656
Main Authors: Hoang Thi, Thai Thanh, Cao, Van Du, Nguyen, Thi Nhu Quynh, Hoang, Duc Thuan, Ngo, Van Cuong, Nguyen, Dai Hai
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical engineering
Biomedical materials
Catalyst
Controlled release
Diagnostic imaging
Diagnostic software
Diagnostic systems
Drug delivery
Drug delivery systems
Electric fields
Energy storage
Fabrication
Materials science
MSN
Nanocarriers
Nanoparticles
Physiochemistry
Porosity
Silica
Silicon dioxide
Stimuli-responsive delivery system
Theranostic applications
Therapeutic applications
Ultrasound
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Summary:Since the first report in early 1990s, mesoporous silica nanoparticles (MSNs) have progressively attracted the attention of scientists due to their potential applications in physic, energy storage, imaging, and especially in biomedical engineering. Owning the unique physiochemical properties, such as highly porosity, large surface area and pore volume, functionalizable, tunable pore and particle sizes and biocompatibility, and high loading cavity, MSNs offer efficient encapsulation and then controlled release, and in some cases, intracellular delivery of bioactive molecules for biomedical applications. During the last decade, functionalized MSNs that show respond upon the surrounding stimulus changes, such as temperature, pH, redox, light, ultrasound, magnetic or electric fields, enzyme, redox, ROS, glucose, and ATP, or their combinations, have continuously revolutionized their potential applications in biomedical engineering. Therefore, this review focuses on discussion the recent fabrication of functionalized MSNs and their potential applications in drug delivery, therapeutic treatments, diagnostic imaging, and biocatalyst. In addition, some potential clinical applications and challenges will also be discussed. •The formation and functionalization of mesoporous silica nanoparticles (MSNs) were discussed.•MSNs were developed as the stimulus-responsive biomaterials.•The potential biomedical applications of MSNs were summarized.•The challenges and future perspectives of MSNs were discussed.
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2019.01.129