Malassezia restricta plays CARDs in the gut

This study shows that Malassezia restricta in the gut acts via CARD9 S12N , a risk factor for Crohn’s disease, to promote the production of inflammatory cytokines in myeloid phagocytes and exacerbate colitis.

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Bibliographic Details
Published in:Nature reviews. Microbiology 2019-05, Vol.17 (5), p.266-267
Main Author: Wrighton, Katharine H.
Format: Article
Language:English
Subjects:
Animals
Antifungal agents
Biomedical and Life Sciences
Colitis
Crohn Disease
Crohn's disease
Cytokines
Disease
Fungi
Fungicides
Gastrointestinal diseases
Gene polymorphism
Genes
Genetic polymorphisms
Immunity
Infectious Diseases
Inflammatory bowel diseases
Innate immunity
Intestine
Life Sciences
Malassezia
Malassezia restricta
Medical Microbiology
Mice
Microbiology
Parasitology
Pathogenesis
Phagocytes
Polymorphism
Research Highlight
Risk analysis
Risk factors
Skin
Virology
Yeast
Yeasts
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Description
Summary:This study shows that Malassezia restricta in the gut acts via CARD9 S12N , a risk factor for Crohn’s disease, to promote the production of inflammatory cytokines in myeloid phagocytes and exacerbate colitis.
ISSN:1740-1526
1740-1534
DOI:10.1038/s41579-019-0188-3