Zinc Supplementation for Promoting Growth in Children Under 5 years of age in Low- and Middle-income Countries: A Systematic Review

Objective To study the effect of zinc supplementation in children under 5 years of age from low- and middle-income countries (LMICs) on anthropometry and prevalence of malnutrition. Design Systematic review of randomized controlled trials and cluster randomized trials. Setting Low- and middle-income...

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Bibliographic Details
Published in:Indian pediatrics 2019-05, Vol.56 (5), p.391-406
Main Authors: Gera, Tarun, Shah, Dheeraj, Sachdev, Harshpal Singh
Format: Article
Language:English
Subjects:
Africa - epidemiology
Anthropometry
Asia - epidemiology
Child Development
Child, Preschool
Developing Countries
Dietary Supplements
Growth Disorders - epidemiology
Growth Disorders - prevention & control
Humans
Infant
Latin America - epidemiology
Malnutrition - epidemiology
Malnutrition - prevention & control
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Randomized Controlled Trials as Topic
Systematic Review
Trace Elements - therapeutic use
Treatment Outcome
Wasting Syndrome - epidemiology
Wasting Syndrome - prevention & control
Zinc - therapeutic use
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Summary:Objective To study the effect of zinc supplementation in children under 5 years of age from low- and middle-income countries (LMICs) on anthropometry and prevalence of malnutrition. Design Systematic review of randomized controlled trials and cluster randomized trials. Setting Low- and middle-income countries. Participants 63 trials with zinc supplementation, incorporating data on 27372 children. Trials conducted exclusively in specifically diseased participants and in children with severe acute malnutrition were excluded. Intervention Zinc supplementation, provided either as medicinal supplementation or through food fortification. Outcome Measures (i) Anthropometry: weight, height, weight-for-height, mid-arm circumference, head circumference; (ii) Prevalence of malnutrition. Results There was no evidence of effect on height-for-age Z score at the end of supplementation period (25 trials; 9165 participants; MD= 0.00 Z; 95% CI -0.07, 0.07; P =0.98; moderate quality evidence) with significant heterogeneity (I 2 = 57%; P
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-019-1537-z