Impact of baseline cigarette smoking status on clinical outcome after transcatheter aortic valve replacement

• Published in: Catheterization and cardiovascular interventions 2019-11, Vol.94 (6), p.795-805
• Main Authors: Abawi, Masieh, Gils, Lennart, Agostoni, Pierfrancesco, Mieghem, Nicolas M., Kooistra, Nynke H. M., Dongen, Charlotte S., Jaarsveld, Romy C., Jaegere, Peter P. T., Doevendans, Pieter A. F. M., Stella, Pieter R.
• Format: Article
• Language: English
• Subjects: Aortic valve; Cigarette smoking; Health risk assessment; Males; Mortality; paradox; Smoking; Stenosis; TAVR
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/ccd.28175

Objectives To explore the prevalence of smoking, and its association with clinical and mortality outcome among patients undergoing transcatheter aortic valve replacement (TAVR). Background Less data exist regarding the effect of baseline smoking status on clinical and mortality outcome among patients undergoing TAVR. Methods Consecutive patients who underwent TAVR at two high volume Dutch centers were included. Smoking status was prospectively questioned by a structured interview at admission. Primary endpoint was 1‐year all‐cause mortality after TAVR. Results A total of 913 consecutive patients (80.1 ± 7.6 years; logistic EuroSCORE: 16.5 ± 9.9%) who underwent TAVR for severe aortic valve stenosis were included. There were 47% (n = 432) males, and 57% (n = 522) never‐smokers, and 35% (n = 317) prior‐smokers, and 8% (n = 74) current‐smokers. Smokers (i.e., prior‐smokers or current‐smokers) were younger compared to never‐smokers (78.9 ± 7.9 and 76.4 ± 8.0 vs. 81.3 ± 7.1, P