Association of lncRNA polymorphisms with triglyceride and total cholesterol levels among myocardial infarction patients in Chinese population

• Published in: Gene 2020-01, Vol.724, p.143684-143684, Article 143684
• Main Authors: Li, Yilan, Zhang, Dandan, Zhang, Yanxiu, Xu, Xueming, Bi, Lei, Zhang, Meiling, Yu, Bo, Zhang, Yao
• Format: Article
• Language: English
• Subjects: Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; Cholesterol - blood; Cholesterol - genetics; Coronary artery disease; Coronary Artery Disease - genetics; Cyclin-dependent kinase inhibitor 2B antisense RNA; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Hypertension - genetics; Male; Metastasis associated lung adenocarcinoma transcript 1; Middle Aged; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide; RNA, Long Noncoding - genetics; Single nucleotide polymorphism; Smoking - genetics; Triglycerides - blood; Triglycerides - genetics
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2019.02.085

The long noncoding RNAs (lncRNAs) have gradually been reported to be an important class of RNAs with pivotal roles in the development and progression of myocardial infarction (MI). In this study, we hypothesized that genetic variant of cyclin-dependent kinase inhibitor 2B antisense RNA (ANRIL) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) may affect the prognosis of MI patients. The study included 401 Han Chinese MI patients and 409 controls. Four lncRNA tag single nucleotide polymorphisms (SNPs)—ANRIL rs9632884 and rs1537373, MALAT1 rs619586 and rs3200401—were selected. SNP genotyping was performed by an improved multiplex ligation detection reaction assay. rs9632884 and rs3200401 SNPs were significantly associated with lipid levels in both controls and MI patients (P  0.05 for all). Taken together, this study provides additional evidence that genetic variation of the ANRIL rs9632884 and MALAT1 rs3200401 can mediate lipid levels in MI patients. •rs9632884 and rs3200401 SNPs were significantly associated with lipid levels in both controls and MI patients.•Those with the rs9632884 GG genotype had lower FBG than those with rs12762303 CC and rs12762303 GC genotypes.•Those with the rs3200401 TT genotype had higher TC levels than those with rs3200401 CT and rs3200401 CC genotypes.•The SNP of rs9632884 interacted with sex to modify CRE levels and to modify the risk of MI.•Several SNPs interacted with age to influence TC (rs9632884) and LDL-C (rs1537373) levels.