Comparison of Reactivity of the Lipid Peroxidation–Antioxidant Defense System in Normal and Hypertensive Rats at Different Stages of Stress-Reaction

We compared changes in the parameters of LPO—antioxidant defense system at various stages of the stress response in mature male ISIAH rats (hereditary stress-induced arterial hypertension) and WAG rats in 3 h (stage of anxiety) and 7 days (resistance stage) after a 3-h single immobilization in the s...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-03, Vol.166 (5), p.613-616
Main Authors: Kolesnikova, L. I., Kolesnikova, L. R., Darenskaya, M. A., Natyaganova, L. V., Grebenkina, L. A., Korytov, L. I., Kolesnikov, S. I.
Format: Article
Language:English
Subjects:
Antioxidants
Anxiety
Biomedical and Life Sciences
Biomedicine
Cell Biology
Glutathione
Hypertension
Immobilization
Internal Medicine
Laboratory Medicine
Lipid peroxidation
Pathology
Rodents
Stress response
Vitamins
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Summary:We compared changes in the parameters of LPO—antioxidant defense system at various stages of the stress response in mature male ISIAH rats (hereditary stress-induced arterial hypertension) and WAG rats in 3 h (stage of anxiety) and 7 days (resistance stage) after a 3-h single immobilization in the supine position. It was found that post-stress reactivity of the nonspecific stress-limiting LPO system is different in normotensive and hypertensive rats. ISIAH rats, irrespective of the stage of the stress-reaction, demonstrated more intense LPO reactions (accumulation of TBA-reactive products) and reduced antioxidant defense parameters (low content of lipid-soluble vitamins, increased oxidized glutathione content) in comparison with the corresponding parameters in WAG rats.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04403-5