Vinorelbine plus Capecitabine (Vinocap): a retrospective analysis in heavily pretreated HER2 negative metastatic breast cancer patients

• Published in: Breast cancer research and treatment 2019-07, Vol.176 (2), p.253-260
• Main Authors: Torres, Alfredo, Ramdial, Jeremy L., Aguirre, Luis E., Mahtani, Reshma, Vogel, Charles L.
• Format: Article
• Language: English
• Subjects: Breast cancer; Cancer; Cancer patients; Cancer research; Capecitabine; Care and treatment; Chemotherapy; ErbB-2 protein; Medicine; Medicine & Public Health; Metastases; Metastasis; Neutropenia; Oncology; Quality of life; Review; Survival; Toxicity; Vinorelbine
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1007/s10549-019-05203-1

Purpose Metastatic breast cancer is regarded as an incurable entity. In heavily pretreated patients with increasingly limited options for palliative management, ensuring proper quality of life continues is to be an elusive issue. With this in mind, the authors evaluated the efficacy and safety of the Vinorelbine/Capecitabine doublet (VINOCAP). Patients and methods The investigators retrospectively analyzed a cohort of 67 women with HER2 negative MBC treated at a large breast cancer practice and a local cancer center with Vinorelbine 22.5 mg/m2 IV on days 1 and 8 combined with Capecitabine 1 g PO BID for 14 consecutive days of 21 day cycles. Patients had been treated with an average of 4 prior lines of chemotherapy. Patient characteristics and outcomes were evaluated. Results A total of 67 patients received VINOCAP, and an additional 2 underwent repeat exposure yielding a cohort of 69. Clinical benefit rate, defined as complete response (CR), partial response (PR) or stable disease ≥ 6 months (SD), was 55.07%. Complete response was seen in 4.34%, PR in 18.8% and SD ≥ 6 months in 31.9%. Median progression-free survival was 6.2 months and overall survival 35.47 months after VINOCAP exposure. The most common grade 3–4 toxicity was neutropenia in 10% of cases. Dose had to be reduced in 18% of cases due to toxicity of any type. The regimen was well tolerated, and serious side effects were uncommon. Conclusion Vinorelbine/Capecitabine appears to be an active and well-tolerated regimen in women with MBC. In particular, encouraging was the efficacy of VINOCAP as fourth or greater line of chemotherapy.