Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin

ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxor...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-03, Vol.166 (5), p.646-650
Main Authors: Men’shchikova, E. B., Zenkov, N. K., Kozhin, P. M., Chechushkov, A. V., Kovner, A. V., Khrapova, M. V., Kandalintseva, N. V., Martinovich, G. G.
Format: Article
Language:English
Subjects:
Antioxidants
Biomedical and Life Sciences
Biomedicine
Cell Biology
Doxorubicin
Drinking water
Drug resistance
Inoculation
Internal Medicine
Laboratory Medicine
Lung cancer
Lung carcinoma
Macrophages
Oncology
Oncolysis
Pathology
Peritoneum
Phenolic compounds
Rodents
Sodium
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a cumulative dose of 8 mg/kg were followed by inhibition of tumor growth by 49.5%. Combined treatment with TS-13 and doxorubicin suppressed the tumor growth by 55.4%. In contrast to doxorubicin, TS-13 inhibited NO generation by peritoneal macrophages. The results show the prospect of studying TS-13 in the context of overcoming drug-resistance of tumors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04410-6