Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi

Filamentous fungi are important microorganisms used in industrial production of proteins and enzymes. Among these organisms, Trichoderma reesei , Aspergilli, and more recently Myceliophthora thermophile are the most widely used and promising ones which have powerful protein secretion capability. In...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2019-04, Vol.35 (4), p.54-10, Article 54
Main Authors: Sun, Xianhua, Su, Xiaoyun
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Environmental Engineering/Biotechnology
Filamentous microorganisms
Fungi
Genetic engineering
Industrial production
Knowledge acquisition
Life Sciences
Microbiology
Microorganisms
Molecular modelling
Proteins
Review
Secretion
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Summary:Filamentous fungi are important microorganisms used in industrial production of proteins and enzymes. Among these organisms, Trichoderma reesei , Aspergilli, and more recently Myceliophthora thermophile are the most widely used and promising ones which have powerful protein secretion capability. In recent years, there have been tremendous achievements in understanding the molecular mechanisms of the secretory pathways in filamentous fungi. The acquired pieces of knowledge can be harnessed to enhance protein production in filamentous fungi with assistance of state-of-the-art genetic engineering techniques.
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-019-2630-0