Therapeutic potential of D prostanoid receptor 1 signal enhancement in a murine model of food allergy

[...]we examined the therapeutic potential of DP1 signal enhancement. Furthermore, BW245C treatment also decreased MMC numbers and serum levels of mMCPT-1 (Fig 2, D-F). Because activation of the Gs-coupled DP1 receptor is known to increase intracellular cAMP levels and previous reports indicate that...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2019-06, Vol.143 (6), p.2290-2293.e4
Main Authors: Nakamura, Tatsuro, Hirai, Rina, Tachibana, Yuri, Masuko, Sakura, Nagata, Nanae, Murata, Takahisa
Format: Article
Language:English
Subjects:
Activation
Allergens
Animal models
Bone marrow
Cell adhesion & migration
Chromatography
Cyclic AMP
Cytokines
Degranulation
Diarrhea
Food allergies
Inflammation
Intestine
Intracellular
Mass spectrometry
Mast cells
Receptor mechanisms
Scientific imaging
Serum levels
Stem cells
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Summary:[...]we examined the therapeutic potential of DP1 signal enhancement. Furthermore, BW245C treatment also decreased MMC numbers and serum levels of mMCPT-1 (Fig 2, D-F). Because activation of the Gs-coupled DP1 receptor is known to increase intracellular cAMP levels and previous reports indicate that an increase in intracellular cAMP levels inhibits mast cell degranulation,9 it is possible that the anti-inflammatory effects of BW245C are mediated through inhibition of mast cell degranulation. BWA868C did not change the degranulation, which suggests that the mast cell–derived PGD2 did not inhibit its own degranulation (Fig 2, H). [...]we believe that DP1 receptor activation exerts a therapeutic effect on food allergen–induced intestinal inflammation by inhibiting both the infiltration and degranulation of mast cells. [...]we demonstrated that enhancing DP1 receptor signaling can exert a preventive and therapeutic effect on development of food allergies by inhibiting infiltration and degranulation of mast cells in the intestines.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.01.039