Comparative assessment of efficacy and safety potential of multifarious lipid based Tacrolimus loaded nanoformulations

[Display omitted] The present work reports the development, optimization and characterization of novel lipid based nanoformulations viz., Liquid crystalline nanoparticles (LCNP), solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) and liposomes loaded with Tacrolimus (Tac) for to...

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Bibliographic Details
Published in:International journal of pharmaceutics 2019-05, Vol.562, p.96-104
Main Authors: Jain, Sanyog, Addan, Ramu, Kushwah, Varun, Harde, Harshad, Mahajan, Rahul R.
Format: Article
Language:English
Subjects:
Drug entrapment
LCNP
Liposomes
NLC
SLN
Tacrolimus
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Summary:[Display omitted] The present work reports the development, optimization and characterization of novel lipid based nanoformulations viz., Liquid crystalline nanoparticles (LCNP), solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) and liposomes loaded with Tacrolimus (Tac) for topical delivery. Different nanoformulations were developed after screening lipids and suitable surfactants depending upon emulsification ability. The various nanoformulations were then optimized (to achieve higher entrapment efficacy, lower particle size, PDI and zeta potential), characterized and loaded into gel. The gels loaded with nanoformulations were also characterized depending upon rheology and viscosity. The gels were analyzed for in vitro drug release, HaCaT cell lines studies and skin permeation studies. The in vivo efficacy studies were carried out using mouse tail model and skin irritation studies using Draize patch test and measurement of TEWL. The developed nanoformulations showed optimum particle size (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.03.042