Late recurrence of medulloblastoma after 17 years of complete remission

•We present a case of medulloblastoma recurrence in an adult after 17 years of diagnosis and initial treatment.•The patient maintains complete remission eighteen months after surgical resection of local recurrence.•To the best of our knowledge only two cases with similar relapse latency has been rep...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2019-06, Vol.64, p.33-35
Main Authors: Vargas López, Antonio Jose, Sola Vendrell, Emma, Fernández Carballal, Carlos
Format: Article
Language:English
Subjects:
Late recurrence
Medulloblastoma
Period of risk
Re-resection
Reirradiation
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Summary:•We present a case of medulloblastoma recurrence in an adult after 17 years of diagnosis and initial treatment.•The patient maintains complete remission eighteen months after surgical resection of local recurrence.•To the best of our knowledge only two cases with similar relapse latency has been reported. To describe an exceptional case of late recurrence of medulloblastoma after 17 years of complete remission. A 42-year-old male consulted in ER for 10-day occipital headache. He had a previous history of cerebellar medulloblastoma 17 years ago treated with gross total resection, chemotherapy and radiotherapy. During his yearly follow-up he had maintained complete remission. MRi showed a cerebellar mass suggestive of medulloblastoma recurrence vs radio-induced tumor. Craniotomy and complete resection of the tumor was performed. The anatomopathological analysis confirmed the recurrence of medulloblastoma. The patient received high dose of adjuvant chemotherapy and he maintains complete remission after 18 months. Recurrence of medulloblastoma may occur despite more than 15 years of complete remission. Because of this fact it is mandatory to continue the follow-up of these patients. Aggressive management of recurrence is recommended in absence of disease dissemination.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2019.03.028