In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration

There are very limited data on ticarcillin-clavulanate elimination by haemofiltration. We measured in vitro ticarcillin-clavulanate adsorption to polyacrylonitrile (PAN) filters and the sieving coefficient using a well-described bench model of haemofiltration. The dose of ticarcillin-clavulanate was...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2019-08, Vol.54 (2), p.261-264
Main Authors: T.P. Wan, Winnie, Guerra Valero, Yarmarly, Choi, Gordon Y.S., Ordóñez Mejia, Jenny L., Wallis, Steven C., Joynt, Gavin M., Lipman, Jeffrey, Gomersall, Charles D., Roberts, Jason A.
Format: Article
Language:English
Subjects:
Clavulanic acid
Critical illness
Pharmacokinetics
Renal replacement therapy
Ticarcillin
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Summary:There are very limited data on ticarcillin-clavulanate elimination by haemofiltration. We measured in vitro ticarcillin-clavulanate adsorption to polyacrylonitrile (PAN) filters and the sieving coefficient using a well-described bench model of haemofiltration. The dose of ticarcillin-clavulanate was 60/2 mg or 180/3 mg, and 0 or 12 g albumin was added to the 1 L of circulating blood-crystalloid mixture to produce four different experimental conditions. The experiment was repeated four times under each condition. Median (interquartile range [IQR] ) ticarcillin adsorption varied from 28 (27-30) mg to 85 (78-90) mg. Adsorption was increased when the dose of ticarcillin was higher (P
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2019.03.018