Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma

Objective Increasing evidence points toward the key function of circular RNAs (circRNAs) in various carcinomas. This study aimed to identify aberrant expression of hsa_circ_0072387 in oral squamous cell carcinoma and probe its clinical significance. Materials and Methods Real‐time quantitative rever...

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Bibliographic Details
Published in:Oral diseases 2019-07, Vol.25 (5), p.1302-1308
Main Authors: Dou, Zhichao, Li, Shaoming, Ren, Wenhao, Wang, Qibo, Liu, Jiacheng, Kong, Xinjuan, Gao, Ling, Zhi, Keqian
Format: Article
Language:English
Subjects:
Bioinformatics
Biomarkers - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
circular RNA
Clinical significance
Computational Biology
Dentistry
Humans
MicroRNAs
Mouth Neoplasms - diagnosis
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Oral cancer
Oral squamous cell carcinoma
Polymerase chain reaction
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription
RNA
Squamous cell carcinoma
Therapeutic applications
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Summary:Objective Increasing evidence points toward the key function of circular RNAs (circRNAs) in various carcinomas. This study aimed to identify aberrant expression of hsa_circ_0072387 in oral squamous cell carcinoma and probe its clinical significance. Materials and Methods Real‐time quantitative reverse transcription–polymerase chain reaction (qRT‐PCR) was used to assess hsa_circ_0072387 expression levels in 63 paired OSCC tissues and three OSCC cell lines. The area under the receiver operator characteristic (ROC) curve was plotted to assess any potential clinical significance. Results Our data showed that hsa_circ_0072387 expression in OSCC was significantly downregulated compared with adjacent normal tissues (p 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13094