A bioluminescent probe for imaging endogenous hydrogen polysulfides in live cells and a murine model of bacterial infection

In this work, we report the first bioluminescent probe BP-PS for detecting H2Sn with high specificity and sensitivity. Owing to the bioluminescence imaging without requiring an excitation light source, tissue autofluorescence is eliminated and BP-PS shows a high signal-to-noise ratio. Moreover, BP-P...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-04, Vol.55 (31), p.4487-4490
Main Authors: Li, Jun-Bin, Wang, Qianqian, Liu, Hong-Wen, Yuan, Lin, Zhang, Xiao-Bing
Format: Article
Language:English
Subjects:
Bacterial infections
Bioluminescence
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Summary:In this work, we report the first bioluminescent probe BP-PS for detecting H2Sn with high specificity and sensitivity. Owing to the bioluminescence imaging without requiring an excitation light source, tissue autofluorescence is eliminated and BP-PS shows a high signal-to-noise ratio. Moreover, BP-PS was successfully utilized to visualize endogenous H2Sn in live cells and a murine model of bacterial infection.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc01699f