Ovarian Carcinosarcoma and Concurrent Serous Tubal Intraepithelial Carcinoma With Next-Generation Sequencing Suggesting an Origin From the Fallopian Tube

Background. Ovarian carcinosarcomas are rare aggressive biphasic tumors. Evidence suggests that these tumors are monoclonal and that the sarcoma component is derived from a stem cell undergoing divergent differentiation. Currently, there remains a paucity of data regarding its origin, with few repor...

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Bibliographic Details
Published in:International journal of surgical pathology 2019-08, Vol.27 (5), p.574-579
Main Authors: See, Sharlene Helene C., Behdad, Amir, Maniar, Kruti P., Blanco, Luis Z.
Format: Article
Language:English
Subjects:
Aged
Carcinosarcoma - diagnosis
Carcinosarcoma - genetics
Carcinosarcoma - secondary
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Cystadenocarcinoma, Serous - diagnosis
Cystadenocarcinoma, Serous - genetics
Cystadenocarcinoma, Serous - secondary
DNA Mutational Analysis
Fallopian Tube Neoplasms - diagnosis
Fallopian Tube Neoplasms - genetics
Fallopian Tube Neoplasms - pathology
Female
High-Throughput Nucleotide Sequencing
Humans
Mixed Tumor, Mullerian - diagnosis
Mixed Tumor, Mullerian - genetics
Mixed Tumor, Mullerian - secondary
Mutation
Ovarian cancer
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - genetics
Ovarian Neoplasms - secondary
Reproductive system
Tumor Suppressor Protein p53 - genetics
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Summary:Background. Ovarian carcinosarcomas are rare aggressive biphasic tumors. Evidence suggests that these tumors are monoclonal and that the sarcoma component is derived from a stem cell undergoing divergent differentiation. Currently, there remains a paucity of data regarding its origin, with few reports suggesting an association with serous tubal intraepithelial carcinoma (STIC) by immunohistochemistry and genetics. Objective. We sought to determine the relationship of carcinosarcoma to high-grade serous carcinoma and STIC by investigating for similar mutation signatures through next-generation sequencing. Methodology. A case of carcinosarcoma with associated high-grade serous carcinoma and STIC was macrodissected, and next-generation sequencing was performed on each component separately. Results. The STIC, high-grade serous carcinoma component, and chondrosarcoma component were all diffusely positive for p53 and p16 by immunohistochemistry. Next-generation sequencing demonstrated an identical TP53 gene c.376-1G>A 5’ splice site pathogenic mutation in all 3 components. Conclusions. Our findings suggest that carcinosarcomas may also originate from the fallopian tube.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896919838347