Vitamin D reduces the serum levels of inflammatory cytokines in rat models of periodontitis and chronic obstructive pulmonary disease

The purpose of this study was to investigate the effects of vitamin D in rat models of chronic obstructive pulmonary disease (COPD) and periodontitis. Animals with both periodontitis and COPD, or with periodontitis only, were established. Once the animal model was established, experimental groups re...

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Bibliographic Details
Published in:Journal of Oral Science 2019, Vol.61(1), pp.53-60
Main Authors: Han, Jing, Cheng, Cheng, Zhu, Zhao, Lin, Mei, Zhang, Dong-Xue, Wang, Zuo-Min, Wang, Songlin
Format: Article
Language:English
Subjects:
Animals
Calcifediol - administration & dosage
Calcifediol - pharmacology
chronic obstructive pulmonary disease
Cytokines - blood
Disease Models, Animal
Inflammation Mediators - metabolism
Injections, Intraperitoneal
Interleukin-1 - blood
Interleukin-10 - blood
Lung - pathology
Lung - physiopathology
Male
periodontitis
Periodontitis - blood
Pulmonary Disease, Chronic Obstructive - blood
RANK Ligand - blood
Rats
Rats, Sprague-Dawley
Respiratory Function Tests
Tumor Necrosis Factor-alpha - blood
vitamin D
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Summary:The purpose of this study was to investigate the effects of vitamin D in rat models of chronic obstructive pulmonary disease (COPD) and periodontitis. Animals with both periodontitis and COPD, or with periodontitis only, were established. Once the animal model was established, experimental groups received intraperitoneal injections of 25-hydroxyvitamin D3 (25-OHD3) for 8 weeks, while control groups received refined peanut oil. After sacrifice, inflammatory status was examined in terms of the serum levels of receptor activator of the nuclear factor κB ligand (RANKL), tumor necrosis factor alpha (TNF-α) and interleukins (IL-1 and IL-10), as well as alveolar bone loss, forced expiratory volume (0.20) (FEV 0.20), and the ratio of FEV0.2 to forced vital capacity. The results showed that 25-OHD3 treatment significantly alleviated inflammation by decreasing the serum levels of RANKL, TNF-α and IL-1 and increasing that of IL-10, while reducing alveolar bone loss and slightly improving lung function. These findings suggest that vitamin D supplementation could be a new clinical approach for the treatment of COPD and periodontitis.
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.17-0357