The myo-inositol effect on the oocyte quality and fertilization rate among women with polycystic ovary syndrome undergoing assisted reproductive technology cycles: a randomized clinical trial

Purpose The aim of the present study was to evaluate the effect of myo-Inositol administration on oocyte quality, fertilization rate and embryo quality in patients with PCOS during assisted reproductive technology (ART) cycles. Methods Fifty infertile PCOS patients were randomly designated in two gr...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2019-06, Vol.299 (6), p.1701-1707
Main Authors: Akbari Sene, Azadeh, Tabatabaie, Azam, Nikniaz, Hossein, Alizadeh, Ahad, Sheibani, Kourosh, Mortezapour Alisaraie, Mona, Tabatabaie, Maryam, Ashrafi, Mahnaz, Amjadi, Fatemehsadat
Format: Article
Language:English
Subjects:
Adult
Clinical trials
Double-Blind Method
Endocrinology
Female
Fertility
Fertilization in Vitro
Folic Acid - pharmacology
Folic Acid - therapeutic use
Gene expression
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Human Genetics
Humans
Infertility, Female - therapy
Inositol - pharmacology
Inositol - therapeutic use
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Oocytes - drug effects
Oocytes - pathology
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - pathology
Quality
Reactive oxygen species
Reproductive Techniques, Assisted - standards
Reproductive technologies
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Summary:Purpose The aim of the present study was to evaluate the effect of myo-Inositol administration on oocyte quality, fertilization rate and embryo quality in patients with PCOS during assisted reproductive technology (ART) cycles. Methods Fifty infertile PCOS patients were randomly designated in two groups. In the study group, patients received daily doses of 4 g myo-Inositol combined with 400 mg folic acid and in the control group patients received only 400 mg folic acid from 1 month before starting the antagonist cycle until the day of ovum pick up. Oocyte and embryo qualities were assessed according to European Society of Human Reproduction and Embryology (ESHRE) guidelines. The gene expression of PGK1, RGS2 and CDC42 as a factor of oocyte quality in granulosa cells was analyzed using real-time RT-PCR. Levels of total antioxidant capacity (TAC) and reactive oxygen species (ROS) were evaluated by chemiluminescence assay in follicular fluid. Results The percentage of metaphase II oocyte, fertilization rate and embryo quality significantly improved in the study group ( p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-019-05111-1