Can pre‐hospital administration reduce time to initial antibiotic therapy in septic patients?

Objective To quantify the potential time saved with pre‐hospital antibiotic therapy in sepsis. Methods Study data for adult patients transported by Ambulance Victoria (AV), and enrolled into the Australasian Resuscitation In Sepsis Evaluation (ARISE), were linked with pre‐hospital electronic records...

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Bibliographic Details
Published in:Emergency medicine Australasia 2019-08, Vol.31 (4), p.669-672
Main Authors: Cudini, Daniel, Smith, Karen, Bernard, Stephen, Stephenson, Michael, Andrew, Emily, Cameron, Peter, Lum, Mark, Udy, Andrew, Bennett, V., Board, J., McCracken, P., McGloughlin, S., Nanjayya, V., Teo, A., Bellomo, R., Bolch, S., Eastwood, G., Kerr, F., Peak, L., Young, H., Edington, J., Fletcher, J., Smith, J., Cross, A., Flemming, D., Grummisch, M., Purdue, A., Coles, T., Connor, H., Dennett, J., Van Berkel, A., Braitberg, G., O'Bree, B., Shepherd, K., Vij, S., Allsop, S., Haji, D., Haji, K., Vuat, J., Bone, A., Elderkin, T., Orford, N., Ragg, M., Dowling, J., Galt, P., Lamac, T., Lightfoot, D., Walker, C., MacIsaac, C., Gorman, K., Jordan, A., Moore, L., Farone, E., Holmes, J., Santamaria, J., Winter, C., Bates, S., Butler, J., French, C., Tippett, A.
Format: Article
Language:English
Subjects:
Aged
Ambulances
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
antibiotics
Emergency Medical Services - methods
Female
Humans
Male
Middle Aged
out of hospital
pre‐hospital
sepsis
Sepsis - drug therapy
Sepsis - mortality
Sepsis - therapy
sepsis management
Survival Analysis
Time Factors
Victoria
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Summary:Objective To quantify the potential time saved with pre‐hospital antibiotic therapy in sepsis. Methods Study data for adult patients transported by Ambulance Victoria (AV), and enrolled into the Australasian Resuscitation In Sepsis Evaluation (ARISE), were linked with pre‐hospital electronic records. Results An AV record was identified for 240 of 341 ARISE patients. The pre‐hospital case notes referred to potential infection in 165 patients. The median time to first antibiotic administration from loading the patient into the ambulance was 107 (74–160) min. Conclusions ARISE patients in Victoria were frequently identified pre‐hospital. An opportunity exists to study the feasibility of pre‐hospital antibiotic therapy.
ISSN:1742-6731
1742-6723
DOI:10.1111/1742-6723.13282