Interaction between the respiratory system and cerebral blood flow regulation

This review summarizes the interaction between the regulatory system of respiration and cerebral vasculature. Some clinical reports provide evidence for the association between these two physiological regulatory systems. Physiologically, arterial carbon dioxide concentration is mainly regulated by t...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2019-11, Vol.127 (5), p.1197-1205
Main Author: Ogoh, Shigehiko
Format: Article
Language:English
Subjects:
Blood flow
Carbon dioxide
Carbon dioxide concentration
Cerebral blood flow
Chronic obstructive pulmonary disease
Control systems
Disease control
Feedback control
Health risks
Lung diseases
Obstructive lung disease
Physiological effects
Physiological factors
Physiology
Regulation
Respiration
Respiratory diseases
Respiratory system
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Summary:This review summarizes the interaction between the regulatory system of respiration and cerebral vasculature. Some clinical reports provide evidence for the association between these two physiological regulatory systems. Physiologically, arterial carbon dioxide concentration is mainly regulated by two feedback control systems: respiration and cerebral blood flow. In other words, both of these systems are sensitive to the same mediator, i.e., carbon dioxide, at a set point. In addition, respiratory dysfunction alters various physiological factors that affect the cerebral vasculature. Therefore, it is physiologically plausible that these systems are closely linked. The regulation of arterial carbon dioxide concentration affected by respiration and cerebral blood flow may be a key factor for a rise in the risk of brain disease in the patients with respiratory dysfunction. For example, the management of respiratory disease (e.g., patients with chronic obstructive pulmonary disease) and the use of prophylactic therapy are essential to reduce the risk of stroke.
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00057.2019