Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Summary Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algori...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2019-04, Vol.17 (4), p.699-707
Main Authors: Diaz, Jose A., Saha, Prakash, Cooley, Brian, Palmer, Olivia R., Grover, Steven P., Mackman, Nigel, Wakefield, Thomas W., Henke, Peter K., Smith, Alberto, Lal, Brajesh K.
Format: Article
Language:English
Subjects:
Animal models
Animals
Blood Coagulation
Consensus
deep vein thrombosis
Disease Models, Animal
electrolytic inferior vena cava model
femoral electrolytic model
ferric chloride model
inferior vena cava (IVC)
Mice
mouse models
recurrent venous thrombosis model
Reproducibility of Results
Rodents
Species Specificity
stasis model
stenosis model
Thrombosis
venous thromboembolism (VTE)
venous thrombosis
Venous Thrombosis - blood
Venous Thrombosis - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Murine models are widely used valuable tools to study deep vein thrombosis (VT). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.14413