Liquid crystalline nanoreservoir releasing a highly skin-penetrating berberine oleate complex for psoriasis management

The current work highlighted preparation of highly penetrating liquid crystalline nanoparticulates (LCNPs) reservoir of a solubility modified berberine oleate (Brb-OL) complex for effective psoriasis management. Brb-OL-loaded LCNPs (Brb-OL-LCNPs) were prepared using hydrotrope method. The proposed B...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-04, Vol.14 (8), p.931-954
Main Authors: Freag, May S, Torky, Abrar S, Nasra, Maha MA, Abdelmonsif, Doaa A, Abdallah, Ossama Y
Format: Article
Language:English
Subjects:
Aqueous solutions
berberine
Disease
Drug delivery systems
Drugs
hydrophobic ion pairing
Lipids
liquid crystalline nanoparticles
Nanoparticles
Permeability
Proteins
Psoriasis
skin penetration
Transdermal medication
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Summary:The current work highlighted preparation of highly penetrating liquid crystalline nanoparticulates (LCNPs) reservoir of a solubility modified berberine oleate (Brb-OL) complex for effective psoriasis management. Brb-OL-loaded LCNPs (Brb-OL-LCNPs) were prepared using hydrotrope method. The proposed Brb-OL-LCNPs showed a particle size of 137 ± 3.7 nm and negative ζ-potential (-38 ± -5.85 mV). Brb-OL-LCNPs showed a threefold increase in the drug accumulated within rat skin and around tenfold increase in the drug permeation compared with crude Brb. studies revealed that topical application of Brb-OL-LCNPs hydrogel significantly alleviated psoriasis symptoms and reduced the levels of psoriatic inflammatory cytokines. Formulating Brb-OL in the LCNPs controlled the release, retention and permeation of the drug across skin layers, which are of prime importance for psoriasis management.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2018-0345